omentin-1 levels and non-alcoholic fatty liver disease in obese adolescents

Background: omentin-1 is an adipocytokine secreted from visceral adipose tissue that is thought to increase insulin sensitivity. non-alcoholic fatty liver disease (nafld) is a comparatively extensive problem in obese adolescents. decreased omentin-1 levels have been reported in obese patients, but the relationship between nafld and omentin-1 is contradictory. objectives: we aimed to evaluate the omentin-1 levels in the sera of obese adolescents with and without nafld and compare them with each other. methods: in this study, a total of 88 adolescents (56 obese and 32 normal-weight) were enrolled. abdominal ultrasonography (us) identified 28 obese adolescents with grade 2 - 3 hepatosteatosis constituting the nafld group and 28 without hepatosteatosis on us constituting the non-nafld group. the control group included 32 age- and gender-matched cases without hepatosteatosis and with normal percentile body mass index (bmi). serum omentin-1 levels were evaluated and compared. results: themeanage of the research group was 12.72±1.91 years. unsurprisingly, bmi, glycated hemoglobin (hba1c), liver transaminases (ast, alt), total cholesterol, triglyceride, low-density lipoprotein cholesterol (ldl), homeostatic model assessment for insulin resistance (homa-ir), and insulin rates were noticeably elevated in obese adolescents compared to controls (p < 0.05). however, omentin-1 and high-density lipoprotein cholesterol (hdl) levels were remarkably lower in the obese group (p < 0.05). no significant difference was found between the nafld and non-nafld groups regarding omentin-1, hba1c, glucose, urea, creatinine, ast, c-reactive protein (crp), total cholesterol, triglyceride, hdl, ldl, thyroid stimulating hormone, 25-hydroxyvitamin d3, homa-ir, and insulin. the bmi and alt grades of the non-nafld group were notably lower than the nafld group (p < 0.05). while there was no significant difference between omentin-1 and other parameters in obese adolescents without nafld (p > 0.05), we found a significant difference between omentin-1 and bmi, ast, alt, homa-ir, and insulin values in obese adolescents with nafld (p < 0.05). conclusions: omentin-1 levels were decreased in obese adolescents regardless of the presence of nafld. however, in obese patients with nafld, there was a significant difference between omentin-1 and several markers of obesity and insulin resistance.