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association between hla-b polymorphisms and autism spectrum disorder in chinese population
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نویسنده
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kang guojun ,kang qi ,zhu xiaojing ,li rixin ,zhang shangchao ,sun yaoyao ,zhang mingyuan ,chen xin ,wang yueying ,jiang huiyi ,yu yaqin ,yu qiong
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منبع
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innovative journal of pediatrics - 2020 - دوره : 30 - شماره : 1 - صفحه:1 -6
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چکیده
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Objectives:the aim of this study was to investigate the association between 2 singlenucleotide polymorphisms (snp) of hlab and autism spectrum disorder (asd).methods:we enrolled 84 asd and 182 healthy children in casecontrol study, and 67 family trios in familybased study. two tag snps (rs1058026, rs2770) in gene hlab were selected to determine the association with asd. chisquare test was used in casecontrol study, haplotype relative risk test (hrr) and transmission disequilibrium test (tdt) analysis were performed in familybased study.results:snp rs1058026 was found significantly associated with asd in familybased study (p = 0.016 for hrr; p = 0.020 for tdt), but not in casecontrol study. conversely, snp rs2770 did not show association with asd in both studies.conclusions:the association observed from this study indicates that gene hlab might play a role in asd in chinese population.
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کلیدواژه
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autism spectrum disorder ,single-nucleotide polymorphisms ,human leukocyte antigen ,hla-b
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آدرس
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jilin university, school of public health, china, jilin university, school of public health, china, jilin university, school of public health, china, jilin university, school of public health, china, jilin university, school of public health, china, jilin university, school of public health, china, jilin university, school of public health, china, jilin university, school of public health, china, jilin university, school of public health, china, jilin university, second part of first hospital, department of pediatrics, china, jilin university, school of public health, china, jilin university, school of public health, china
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پست الکترونیکی
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yuqiong@jlu.edu.cn
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Authors
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