analysis of outcome of intraplueral streptokinase in pediatric empyema thoracis even in advanced stages: a prospective study

Background: empyema thoracis in children causes significant morbidity. standard treatment of empyema thoracis includes tube drainage and antibiotics. but the tube drainage often fails. intrapleural streptokinase has been used in empyema thoracis with good success rate. objectives: we evaluated the efficacy of intra-pleural streptokinase in management of empyema thoracis even in advanced stages. patients and methods: a total of 28 patients with empyema thoracis requiring intercostal tube drainage aged zero to twelve years were included in the study who were admitted in pediatric intensive care unit. 15,000 units/kg of streptokinase was instilled into the pleural cavity. response was assessed by clinical outcome, after unclamping and subsequent chest radiography and serial chest ultrasounds. results: streptokinase enhanced drainage in all patients with complete resolution of empyema thoracis in 26 patients. two patients were referred for surgery. only 7.2% required surgery. streptokinase was equally effective if started before or after seven days. conclusions: intrapleural streptokinase is the preferred treatment for treating pediatric empyema thoracis even in advanced stages and can avoid surgery.