bilineal acute leukemia associated with fanconi syndrome: the first case report

Fanconi syndrome is a metabolic disorder involving dysfunction of the renal proximal tubules, resulting in excessive urinary excretion of several metabolites. various factors may lead to fanconi syndrome, as it may be a genetic disease with primary or secondary etiologies, or may be acquired. in this study, we report a unique case of fanconi syndrome with development of a relatively rare acute leukemia, a condition that has not been reported before. the case was an 8-year-old boy with familial occurrence of fanconi syndrome, presenting with pallor, asthenia, recurrent infections, growth failure, and a variety of biochemical and hematological abnormalities. after physical examination, radiographic studies, and comprehensive laboratory analyses, fanconi syndrome associated with bilineal acute leukemia, of myeloid and t-lymphoid lineages, was diagnosed.