does ketamine is safe and effective for procedural sedation in percutaneous liver biopsy in children? a cohort study in iran

Background: effective and safe procedural sedation is necessary for percutaneous liver biopsy in children. there are a number of different protocols for this purpose. the current study investigated ketamine and dpt cocktail (meperidine (demerol®) + promethazine (phenergan®) + chlorpromazine (thorazine®)). methods: the current cohort of 80 iranian children aimed at investigating percutaneous liver biopsy. each of the 2 study groups (ketamine and dpt) included 40 patients. both groups were matched by age (number of participants under and above 7 years old). the current study evaluated the efficacy of 2 protocols by cheops (children’s hospital of eastern ontario pain scale) and visual analogue scale (vas) pain scoring system and sedation scoring a,b,c, and d. results: ketamine group was sedated and recoveredmuchmorerapidly than the dpt receiving patients. also, they had significantly less pain during the biopsy. the mostcommonside effect of ketamine was vomiting (27%); in the other group, transient hypotension and tachycardia were more common. conclusions: ketamine is a safe and effective choice for procedural sedation in percutaneous liver biopsy in children.