تاثیر درمان غیرجراحی پریودنتال بر سطح هموگلوبین گلیکوزیکه در افراد غیردیابتی مبتلا به پریودنتیت مزمن : یک مطالعه کارآزمایی بالینی

ﻣﻘﺪﻣﻪ: ﻫﺪف اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﺑﺮرﺳﯽ ﺳﻄﺢ ﻫﻤﻮﮔﻠﻮﺑﯿﻦ ﮔﻠﯿﮑﻮزﯾﻠﻪ glycosylated hemoglobin hba1c و در اﻓﺮاد ﻣﺒﺘﻼ ﺑﻪ ﭘﺮﯾﻮدﻧﺘﯿﺖ ﻣﺰﻣﻦ ﻏﯿﺮ دﯾﺎﺑﺘﯽ و ﺗﺄﺛﯿﺮ درﻣﺎن ﻏﯿﺮﺟﺮاﺣﯽ ﭘﺮﯾﻮدﻧﺘﺎل ﺑﺮ ﺳﻄﺢ hba1c ﺧﻮن ﺑﻮد.ﻣﻮاد و روش ﻫﺎ: در اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﮐﺎرآزﻣﺎﯾﯽ ﺑﺎﻟﯿﻨﯽ، ﺗﻌﺪاد 40 ﻧﻔﺮ اﻓﺮاد ﻏﯿﺮ دﯾﺎﺑﺘﯽ 30 ﺗﺎ 50 ﺳﺎﻟﻪ در دو ﮔﺮوه ﻣﺪاﺧﻠﻪ و ﮐﻨﺘﺮل وارد ﻣﻄﺎﻟﻌﻪ ﺷﺪﻧﺪ. ﮔﺮوه ﻣﺪاﺧﻠﻪ، ﺷﺎﻣﻞ 20 ﻧﻔﺮ ﺑﯿﻤﺎر ﻏﯿﺮدﯾﺎﺑﺘﯽ ﻣﺒﺘﻼ ﺑﻪ ﭘﺮﯾﻮدﻧﺘﯿﺖ ﻣﺰﻣﻦ و ﮔﺮوه ﮐﻨﺘﺮل ﺷﺎﻣﻞ 20 ﻧﻔﺮ ﻣﺮد ﻏﯿﺮدﯾﺎﺑﺘﯽ دارای ﭘﺮﯾﻮدﻧﺸﯿﻮم ﺳﺎﻟﻢ ﺑﻮدﻧﺪ.ﭘﺎراﻣﺘﺮﻫﺎی ﮐﻠﯿﻨﯿﮑﯽ ﭘﺮﯾﻮدﻧﺘﺎل ﺷﺎﻣﻞ ﻋﻤﻖ ﭘﺮوﺑﯿﻨﮓ ﭘﺎﮐﺖ ppd ، از دﺳﺖ رﻓﺘﻦ ﭼﺴﺒﻨﺪﮔﯽ ﮐﻠﯿﻨﯿﮑﯽ cal ، ﺷﺎﺧﺺ ﻟﺜﻪ ای gi و hba1c ﺗﻤﺎﻣﯽ اﻓﺮاد اﻧﺪازه ﮔﯿﺮی ﺷﺪ. درﻣﺎن ﻏﯿﺮﺟﺮاﺣﯽ ﭘﺮﯾﻮدﻧﺘﺎل nspt ﺑﺮای ﮔﺮوه ﻣﺪاﺧﻠﻪ اﻧﺠﺎم ﺷﺪ. ﭘﺲ از ﺳﻪ ﻣﺎه ﭘﺎراﻣﺘﺮﻫﺎی ﮐﻠﯿﻨﯿﮑﯽ ﭘﺮﯾﻮدﻧﺘﺎل و hba1c اﻧﺪازه ﮔﯿﺮی و ﺑﺎ ﻧﺘﺎﯾﺞ اوﻟﯿﻪ ﻣﻘﺎﯾﺴﻪ ﺷﺪ. ﯾﺎﻓﺘﻪ ﻫﺎ: ﻗﺒﻞ از درﻣﺎن ﻏﯿﺮ ﺟﺮاﺣﯽ ﭘﺮﯾﻮدﻧﺘﺎل ﺳﻄﺢhba1c در ﮔﺮوه ﻣﺪاﺧﻠﻪ ﺑﯿﺸﺘﺮ از ﮔﺮوه ﮐﻨﺘﺮل ﺑﻮد001. p<0/ در ﮔﺮوه ﻣﺪاﺧﻠﻪ ﺳﻄﺢ hba1c ﻗﺒﻞ و ﺑﻌﺪ از درﻣﺎن ﻏﯿﺮﺟﺮاﺣﯽ ﭘﺮﯾﻮدﻧﺘﺎل ﺑﻪ ﺗﺮﺗﯿﺐ 5/45±0/62 و 69 /5/23±0 درﺻﺪ ﺑﻮد ﮐﻪ ﻧﺸﺎن دﻫﻨﺪه اﺧﺘﻼف ﻣﻌﻨﺎدار ﺑﻮد p<0/001 . در ﺣﺎﻟﯽ ﮐﻪ در ﮔﺮوه ﮐﻨﺘﺮل ﺳﻄﺢ hba1c ﻗﺒﻞ و ﺑﻌﺪ اﺧﺘﻼف ﻣﻌﻨﺎداری را ﻧﺸﺎن ﻧﻤﯽ داد 0/66 = p .ﻧﺘﯿﺠﻪ ﮔﯿﺮی: اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﻧﺸﺎن داد ﮐﻪ ﭘﺮﯾﻮدﻧﺘﯿﺖ ﻣﺰﻣﻦ ﻣﯽ ﺗﻮاﻧﺪ ﺑﺮ روی ﮐﻨﺘﺮل ﻗﻨﺪ ﺧﻮن اﻓﺮاد ﺳﺎﻟﻢ ﺗﺄﺛﯿﺮ ﺑﮕﺬارد. درﻣﺎن ﻏﯿﺮﺟﺮاﺣﯽ ﭘﺮﯾﻮدﻧﺘﺎل ﺑﺎﻋﺚ ﺑﻬﺒﻮد ﺳﻼﻣﺘﯽ ﻧﺴﺞ ﭘﺮﯾﻮدﻧﺸﯿﻮم ﻣﯽ ﺷﻮد و ﺳﻄﺢ hba1c را ﮐﺎﻫﺶ ﻣﯽ دﻫﺪ

the effect of non-surgical periodontal treatment on the glycosylated hemoglobin levels of non-diabetic patients with chronic periodontitis: a clinical trial

this study aimed to investigate the level of glycosylated hemoglobin (hba1c) in non-diabetic subjects with chronic periodontitis and the effect of non-surgical periodontal treatment on hba1c levels.materials and methods: in this clinical trial study, 40 non-diabetic patients between 30 to 50 years old were enrolled and divided to case and control groups based on their periodontal health. the case group included 20 non-diabetic subjects with chronic periodontitis and the control group included 20 non-diabetic subjects with healthy periodontium. clinical periodontal parameters including pocket probing depth (ppd), clinical attachment loss (cal), gingival index (gi), and glycosylated hemoglobin (hba1c) were measured in all subjects. the case group received non-surgical periodontal therapy (nspt). subjects were re-evaluated for periodontal parameters and hba1c after three months.results: prior to non-surgical periodontal treatment, hba1c levels were significantly higher in the case group compared to the control group (p< 0. 001). hba1c levels before and after non-surgical periodontal treatment in the case group were 5/45±0/62% and 5/23±0/69%, respectively, which was statistically significant (p<0. 0001). howere in the control group, hba1c levels did not show any significant changes over the three months of study (p=0.66).conclusion: this study showed that chronic periodontitis could affect glycemic control in otherwise systemically healthy individuals. periodontal therapy improved periodontal health status and decreased hba1c levels.