اثربخشی درمان با میدان مغناطیسی بر خستگی مبتلایان به مولتیپل اسکلروزیس-کارآزمایی بالینی تصادفی و یک سوکور: یک گزارش کوتاه

زمینه و هدف: خستگی یکی از ناتوان‌کننده‌ترین علایم در بیماران مبتلا به مولتیپل اسکلروزیس (ms) می‌باشد که تاکنون درمان قطعی برای آن ثبت نشده است. مطالعه حاضر با هدف بررسی اثربخشی درمان با میدان مغناطیسی بر خستگی مبتلایان به ms انجام شد.روش بررسی: این مطالعه به‌صورت کارآزمایی بالینی تصادفی یک سوکور از فروردین سال 1398 تا شهریور سال1400 بر روی 46 بیمار مبتلا به ms انجام شد. بیماران به‌طور تصادفی به دو گروه مداخله مگنتوتراپی و گروه کنترل تقسیم شدند. مداخله به‌صورت میدان مغناطیس پالسی با فرکانس hz 15 و شدت mt 5/4 انجام شد.یافته‌ها: متوسط شدت خستگی در گروه مداخله از 91/4 به 27/4 و در گروه کنترل نیز از83/4 به 37/4 کاهش یافت که از نظر آماری معنادار بودند (به‌ترتیب 024/0p= و 028/0p=). اما اختلاف پاسخ دو گروه به درمان از نظر آماری معنادار نبود (382/0=p).نتیجه‌گیری: با توجه به عدم اختلاف چشمگیر درکاهش خستگی، شدت خستگی، این روش درمانی برای درمان خستگی بیماران ms توصیه نمی‌شود.

The effectiveness of magnetic field therapy on fatigue in patients with multiple sclerosis-a randomized, single-blind clinical trial: a brief report

Background: Multiple sclerosis (MS), as an inflammatory autoimmune disease and chronic degenerative central nervous system degeneration, often occurs in early adulthood. One of the common and debilitating symptoms of this disease is fatigue, which can affect up to 80% of patients with MS. This study aimed to evaluate the effectiveness of magnetic field therapy on fatigue in patients with MS.Methods: Present study is a singleblind randomized clinical trial (RCT) that Was conducted on patients with multiple sclerosis from March 2019 to September 2021. In this study, 46 patients who met our inclusion criteria were divided into two groups randomly: magnetotherapy intervention and control group. The intervention was performed in the form of a pulsed magnetic field with a frequency of 15 Hz and an intensity of 4.5 Millie Tesla. In order to blind patients, they were unaware of the intervention or control group, and the technician in charge of the treatment and the statistician knew about it. Data were then collected and recorded using the Fatigue Severity Scale, the Patient Health Questionnaire, and the Epworth Sleepiness Scale Questionnaire.Results: Of the 46 patients studied, 22 (48%) were male and the rest of them were female [24 cases (52%)]. The mean age of men and women was 34.4 ±7.3 and 33.5 ±1.7 years, respectively. Among the intervention and control groups, 8 people took amantadine equally in each group. In the magnetotherapy intervention group, the mean severity of fatigue reduced from 4.91 ±0.86 to 4.27 ±1.10, which was significant (p=0.024). In our control group, the mean intensity of fatigue reduced from 4.83 ±0.83 to 4.37 ±0.81, which was significant statistically (p=0.028). Although, the difference between the response of the two groups to treatment was not significant (p=0.382).Conclusion: Due to the lack of significant differences in the reduction of fatigue severity, this treatment is not recommended for the treatment and management of fatigue in patients with MS.