a medication assessment tool to evaluate prescribers’ adherence to practice guidelines in acute-phase schizophrenia treatment: development and psychometric properties

Background: studies showed that the adherence to practice guidelines is associated with a higher quality of care and better patient’s outcomes. in psychiatric practice, there is a quality gap between practice guidelines (pgs) and routine clinical practice for the patients with schizophrenia which potentially hinders their recovery. one of the important reasons for this persistent gap is the lack of systematic methods to evaluate prescribers’ adherence to practice guidelines. objectives: this study aimed to develop and validate a medication assessment tool (mat) to evaluate prescribers’ adherence to pharmacotherapy recommendations in pgs during the acute phase of schizophrenia (apscz) in iran (mat apscz). methods: this methodological cross-sectional study was conducted from august 2021 to april 2022. according to the literature review and discussions in the research group, an item pool of 91 items was developed. then face and content validity of the scale were evaluated. then, exploratory factor analysis (efa) was used to specify the factor structure. at last, the reliability and responsiveness of the scale were assessed. the study sample consisted of 200 iranian psychiatrists and final-year psychiatry residents. results: eleven items were merged in qualitative content validity. then, sixteen and six items were excluded from the scale in terms of having low content validity ratios and corrected item-total correlation, respectively. in exploratory factor analysis, the remaining 48 items were classified into six factors, which included 50.1% of the total variance. based on the results, cronbach’s alpha, and mcdonald’s omega of all factors were higher than 0.7, aic was 0.2 to 0.4 for all factors, and the intraclass correlation coefficient for mat apsczwas 0.914. the standard error of measurement was ± 4.5, and the percentage of minimum detectable change for the tool was calculated to be 6.15%, which indicates its excellent responsiveness. conclusions: the mat apsczhas acceptable psychometric properties and could be a useful tool to evaluate prescribers’ adherence to practice guidelines pharmacotherapy recommendations during the apscz.