The effect of TGF-alpha on neurogenesis in sub ventricular zone of rat brain after ischemia-reperfusion

Introduction: stroke is the third important reason of death in adults and an important cause of adult disability. previous studies suggest that tgf-alpha can induce neurogenesis after stroke. here in, we studied neurogenesis effects of the tgf-alpha on subventricular zone following ischemia-reperfusion. methods: male wistar rats (250-300 g) were divided into ischemia and treatment groups. after inductreion of ischemia-reperfusions, pbs (phosphate buffer salin) and tgf-alpha 50 ng were injected stereotaxicaly in lateral ventricle in ischemia and treatment respectively. after 12 days, the nestin expression in subventricular zone was assessed by immunohistochemical staining method. results: our results showed that nestin expression increased significantly in treatment group in comparison with ischemia group (p<0.05). discussion: expression of nestin in svz indicates that tgf- a can stimulate the neural stem cells proliferation after ischemia - reperfusion injury.