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Ecstasy-induced caspase expression alters following ginger treatment
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نویسنده
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asl s.s. ,pourheydar b. ,dabaghian f. ,nezhadi a. ,roointan a. ,mehdizadeh m.
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منبع
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basic and clinical neuroscience - 2013 - دوره : 4 - شماره : 4 - صفحه:329 -333
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چکیده
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Introduction: exposure to 3-4, methylenedioxymethamphetamine (mdma) leads to cell death. herein, we studied the protective effects of ginger on mdma- induced apoptosis. methods: 15 sprague dawley male rats were administrated with 0, 10 mg/kg mdma, or mdma along with 100mg/kg ginger, ip for 7 days. brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by rt-pcr. data was analyzed by spss 16 software using the one-way anova test. results: mdma treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p<0.001). ginger administration however, appeared to significantly decrease the same (p<0.001). discussion: our findings suggest that ginger consumption may lead to the improvement of mdma-induced neurotoxicity.
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کلیدواژه
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Apoptosis; Caspase; Ginger; MDMA
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آدرس
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hamadan university of medical sciences, ایران, urmia university of medical sciences, ایران, research institute for islamic and complementary medicine, tehran university of medical sciences, ایران, aja university of medical sciences, ایران, hamadan university of medical sciences, ایران, tehran university of medical sciences tums, ایران
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Authors
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