Effects of Hydroalcoholic Extract of Tanacetum Sonbolii (Asteraceae) on Pain-related Behaviors during Formalin Test in Mice

Introduction: tanacetum sonbolii (asteraceae) is an endemic species in iran. in the present study, we examined the effects of tanacetum sonbolii hydroalcoholic extract on the formalin test in mice. methods: 126 swiss albino mice weighing 230-280g were used as subjects. the formalin test was performed on two control groups (marked as intact and saline groups; n = 6 in each group) and an experimental group. in all groups, the formalin test was recorded for 60 min after administration of extract and drugs in mice. results: the results showed that tanacetum sonbolii (150 and 300 mg/kg) produced significant antinociception in phase 2. in addition, different doses of tanacetum sonbolii extract (600, 900 and 1200 mg/kg) also induced antinociceptive effects in phase1 and phase 2. on the other hand, morphine could induce antinociception in a dose-dependent manner. diclofenac (10 mg/kg) failed to affect the pain scores compared to tanacetum sonbolii (300 mg/kg) group. discussion: it seems that administration of hydroalcoholic extract of tanacetum sonbolii has the potential to relieve pain through both central and peripheral mechanisms in persistent inflammatory nociception.