Case Report: Combination Therapy With Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in A Case of Spinal Cord Injury

introduction: various neuroregenerative procedures have been recently employed along withneurorehabilitation programs to promote neurological function after spinal cord injury (sci),and recently most of them have focused on the acute stage of spinal cord injury. in this report,we present a case of acute sci treated with neuroprotective treatments in conjunction withconventional rehabilitation program.methods: a case of acute penetrative sci (gunshot wound), 40 years old, was treated withintrathecal bone marrow derived stem cells and parenteral granulocyte-colony stimulatingfactor (g-csf) along with rehabilitation program. the neurological outcomes as well as safetyissues have been reported. results: assessment with american spinal injury association (asia), showed neurologicalimprovement, meanwhile he reported neuropathic pain, which was amenable to oral medication. discussion: in the acute setting, combination therapy of g-csf and intrathecal mesenchymalstem cells (mscs) was safe in our case as an adjunct to conventional rehabilitation programs.further controlled studies are needed to find possible side effects, and establish net efficacy.