exploring the role of micrornas and associated proteins in multiple sclerosis

Introduction: multiple sclerosis (ms) is a chronic autoimmune disease affecting the central nervous system (cns). the diagnosis and follow-up of ms progression are challenging because of its complex pathogenesis and the lack of specific biomarkers. this study aims to introduce related micrornas (mirnas) and associated proteins with ms. methods: ms-related mirna data of 4 peripheral blood profiles from relapsing-remitting ms patients and 8 healthy controls were extracted from the geo database. their related proteins were analyzed using bioinformatics methods, such as protein-protein interaction (ppi) network and action map. results: eighteen differential microrna were detected, discriminating the patient samples from controls. then, 31 related proteins were identified and assessed via ppi network analysis and action map evaluation.conclusion: in conclusion, a protein panel of ncl, nop58, snrnp70, u2af2, ybx1, prpf8, bop1, and pik3k as the crucial individuals associated with ms are suggested for further investigation.