comparing the seizure-induced impairment of short-term plasticity in dorsal and ventral hippocampus in kindled mice

Introduction: the differences among dorsal and ventral hippocampal neural circuits affect synaptic plasticity. in this study, we aim to compare the occurrence of short-term plasticity in the field excitatory postsynaptic potential (fepsp) in dorsal and ventral hippocampal ca1 areas following kindled seizures. methods: animals (male c57 b6/j mice, 12 weeks of age) were kindled by intraperitoneal injections of pentylenetetrazole (ptz), and fepsps were recorded from dorsal and ventral hippocampal slices. short-term plasticity was evaluated by measuring fepsp-slope and fepsp-area following paired-pulse stimulation delivered at three inter-pulse intervals (20, 80, and 160 ms). results: in control slices, the fepsp-slope was greater in the ventral hippocampus compared to the dorsal hippocampus, but there was no difference in the fepsp-area between the two regions. in hippocampal slices, the fepsp-slope was similar in the dorsal and ventral regions, but the fepsp-area was greater in the ventral region compared to the dorsal region. in addition, the fepsp-area was greater in the kindled group than in the control group only in the ventral hippocampus. ptz-induced kindled slices showed impaired short-term facilitation, and the paired-pulse index decreased only in the dorsal hippocampus. kindling had no significant effect on the paired-pulse ratio in the ventral hippocampus. conclusion: the seizure occurrence affects the neural activity of the hippocampus in a region-dependent manner. although kindling increases the fepsp area in the ventral hippocampus of mice, kindling-induced changes in short-term synaptic plasticity are significant only in the dorsal hippocampus. the difference in the responses of dorsal and ventral poles should be considered in future studies.