the effect of omega-3 supplementation on serum levels of antioxidant status in patients with bipolar disease: a randomized double-blind controlled clinical trial

Introduction: antioxidants prevent the progression of neuropsychiatric disorders, such asbipolar disorder (bd). omega-3 fatty acid supplementation helps prevent lipid peroxidationand improve antioxidant status. this study aims to investigate the effect of omega-3supplementation on serum levels of antioxidant status in patients with bd.methods: in this study, 28 patients with bd received an omega-3 fatty acid supplement (2g/daily) while the other 28 patients received edible paraffin oil (2 g/daily) for 60 days. theactivities of superoxide dismutase (sod), catalase (cat), and total antioxidant capacity(tac) were evaluated in pre-intervention and post-intervention.results: the results showed that omega-3 supplementation increased the activities of sod(12.94±3.84 u/ml vs 17.72±3.59 u/ml) and cat (5.08±1.61 nmol/min/ml vs 6.43±1.33nmol/min/ml) in post-intervention compared to pre-intervention (p=0.001). the results alsoshowed that omega-3 supplementation increased the activities of sod (17.72±3.59 u/ml vs13.79±3.12 u/ml) and cat (6.43±1.33 nmol/min/ml vs 4.89±1.45 nmol/min/ml) comparedto the control group in post-intervention (p=0.001). omega-3 supplementation did not havesignificant effects on the serum concentration of tac compared to pre-intervention (p=0.373)and control group (p=0.604).conclusion: omega-3 supplementation increased the activities of sod and cat and maydecrease the progression of disease via increasing antioxidant status.