pattern of neuroinflammatory mirnas, c-reactive protein and alanine aminotransferase in hospitalization in recovered or not-recovered covid-19 patients

Introduction: our aim was to investigate the expression of mirnas, c-reactive protein as a blood inflammation marker, and alanine aminotransferase as a tissue inflammation marker, in recovered and not-recovered covid-19 patients.methods: this cross-sectional project was conducted at three medical centers in iran from december to march 2021. in total, 20 confirmed cases of covid-19 with grade iii severity and 20 healthy subjects were enrolled in the study. subsequently, the neuroinflammatory expression of mirnas (mir-199, mir-203, and mir-181), c-reactive protein, and alanine aminotransferase was investigated during hospitalization from week 0 to week 2.results: among covid-19 subjects who did not recover, the expression levels of mir-199, mir-203, and mir-181 were decreased, while the levels of c-reactive protein and alanine aminotransferase increased during hospitalization. conversely, in recovered covid-19 subjects, the relative expression of mir-199, mir-203, and mir-181 increased and the levels of c-reactive protein and alanine aminotransferase decreased during hospitalization.conclusion: the expression pattern of neuroinflammatory mirnas depends on whether the covid-19 patient is recovering or deteriorating. their expression is downregulated in covid-19 patients who do not recover and upregulated in those who do recover.