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Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior
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نویسنده
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mirfazeli fatemeh sadat ,mohebi fatemeh ,jahanbakhshi amin ,aryani omid ,almasi-dooghaee mostafa
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منبع
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basic and clinical neuroscience - 2022 - دوره : 13 - شماره : 6 - صفحه:893 -900
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چکیده
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Wolfram syndrome (ws) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. a 26-year-old man was reported with classic symptoms of ws and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. the genetic study demonstrated a novel homozygous stop-codon mutation on the wfs1 gene. this special type of mutation may be related to repetitive suicidal behaviors in this case of ws. psychological support should be a routine practice in patients with ws.
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کلیدواژه
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Wolfram syndrome ,Suicidal behavior ,Gene ,Mutation ,WFS1 gene
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آدرس
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iran university of medical sciences, mental health research center, psychosocial health research institute, Iran, iran university of medical sciences, school of medicine, department of psychiatry, Iran, iran university of medical sciences, skull base research center, rasool akram hospital, department of neurosurgery, Iran, tehran university of medical sciences, endocrinology and metabolism research institute, Iran. iran university of medical sciences, faculty of new medical technologies, department of neuroscience, Iran, iran university of medical sciences, firoozgar hospital, department of neurology, Iran
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پست الکترونیکی
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almasidoghaei.m@iums.ac.ir
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Authors
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