shielding effect of ryanodine receptor modulator in rat model of autism

Introduction: a neurodevelopmental disorder, autism is typically identified with three primary behavioral consequences, such as social impairment, communication problems, and limited or stereotypical behavior. because of its co-morbidity and lack of therapeutic options, autism is a global economic burden. a short chain of fatty acid, propionic acid is formed biologically by the gut microbiome. propionic acid levels that are too high can cause leaky intestines, which can lead to autism-like symptoms. methods: to induce autism, male albino wistar rats were given propionic acid (250 mg/ kg/po on the 21st, 22nd, and 23rd postnatal days). rats also received a ryanodine receptor antagonist (ruthenium red: 3 mg/kg/po; postnatal 21st to 50th day) to see what influence it had on propionic acid-induced autism. anxiety, social behavior, and repeated behaviors were all assessed, as well as oxidative stress, inflammatory indicators, neuro signaling proteins, and blood-brain barrier permeability. results: ruthenium red was found to counter the propionic acid-induced increases in anxiety, repetitive behavior prefrontal cortex levels of il-6, tnf-α, tbars, evans blue leakage, and water content along with decreases in social behavior, il-10, and gsh followed by hippocampus creb and bdnf levels. conclusion: ryanodine receptor antagonists presented a neuroprotective effect in propionic acid-induced conditions like autism by modulatory effects on social and repetitive behavior, oxidative stress, neuroinflammation, and neuroprotein changes. ryanodine receptors can be further explored in depth to manage autism as a condition.