the association between fennel extract, serum lipid profile, and leptin receptor expression

Introduction: obesity is among the most severe challenges of our era, with significanthealth consequences and a high economic burden for health systems. therefore, manycountries have developed political agendas to cope with this ever-rising challenge. alongwith chemical medications developed to manage obesity, researchers have focused on somenatural ingredients and herbal extracts that are effective in reducing weight. the current studyinvestigated the association between foeniculum vulgar (fennel) extracts and body weight,lipid profile, and leptin.methods: in total, 35 adult male balb/c mice were investigated in sham, fennel 50 mg/kg, fennel100 mg/kg, and fennel 200 mg/kg (n=7) groups. the mice were administered fennel extracts forfourteen days while weighted at the intervention’s beginning and end. then, their weight, lipidprofile, serum leptin, and expression of leptin protein in the hypothalamus were measured.results: after providing the intervention, leptin receptor protein expression was increasedin all groups, while serum leptin didn’t change significantly. moreover, a significant decreasewas observed in the cholesterol dose of 100 mg/kg/day, triglycerides in 100 and 200 mg/kg/day, and ldl in 50 and 100 mg/kg/day. serum hdl was increased significantly in a dose of100 mg/kg/day.conclusion: fennel extract can decrease the lipid profile by changing the expression of theleptin receptor.