the role of oxidant-antioxidant status in suicide behavior in kurdish ethnicity

Introduction: oxidative stress plays a critical role in the pathogenesis of neurodegenerativeand neuropsychiatric disorders. however, its role in suicidal behavior has not been clarifiedyet. consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicideattempters in ilam city.methods: fifty suicide attempters and 40 control subjects (volunteers) aged 18-35 years werestudied in the current experiment. to consider the oxidant-antioxidant status, serum levels ofmalondialdehyde (mda), nitric oxide (no), superoxide dismutase (sod), and the totalantioxidant capacity (tac) were measured.results: serum levels of sod and tac were significantly lower in the suicide attemptersgroup compared to the controls. furthermore, serum no level was significantly higher in thesuicide attempters compared to the control groups. interestingly, the serum level of mda wassignificantly lower in the suicide attempters compared to the control groups.conclusion: the oxidative stress without mda elevation, detected in suicide attempters, canbe considered a biochemical hallmark in suicide behavior.