Effects of Celecoxib Adjunct To Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder

Introduction: inflammatory processes in the brain play an important role in theetiopathogenesis of obsessive-compulsive disorder (ocd). cyclooxygenase inhibitors, suchas celecoxib reduce the production of proinflammatory cytokines. this double-blind studyaimed to investigate the effects of adding celecoxib to selective serotonin reuptake inhibitors(ssris)on treating ocd.methods: sixty patients who met the diagnosis criteria for ocd based on the diagnostic andstatistical manual of mental disorders -fourth edition- text revision (dsm-iv-tr) wererecruited in the present study. two psychiatrists independently confirmed the diagnosis byperforming structured interviews. the study participants included 23 patients who receivedssris and celecoxib (400 mg twice daily) and 22 patients in the control group that receivedssris and placebo. moreover, at baseline, in weeks 4, 8, and 12, the explored patients wereassessed by a psychiatrist using the yale-brown obsessive-compulsive scale (y-bcos).results: a significant difference was observed in the change of scores on the y-bocs in week12, compared with the onset of the study between the study groups (t= -8.976, df=38, p=0.001).there was a significant difference between the study groups in obsession (f= 49.19, df= 1,p≤0.001), compulsion (f= 13.78, df= 1, p= 0.001), and ocd (f= 57.25, df= 1, p≤0.001), i.e.,higher in the celecoxib group.