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Mdma and the Brain: A Short Review on the Role of Neurotransmitters in Neurotoxicit
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نویسنده
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Mustafa Nor Suliana ,Abu Bakar Nor Hidayah ,Mohamad Nasir ,Adnan Liyana Hazwani Mohd ,Fauzi Nurul Farah Aina Md ,Thoarlim Abdulsoma ,Syed Omar Syed Hadzrullathfi ,Hamzah Mohd Shafiee ,Yusoff Zawawi ,Jufri Mahdi ,Ahmad Rashidi
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منبع
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Basic And Clinical Neuroscience - 2020 - دوره : 11 - شماره : 4 - صفحه:381 -388
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چکیده
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N-methyl-3, 4-methylenedioxyamphetamine (mdma), or ecstasy is a recreational drug of abuse. it is a synthetic substance that affects the body 's systems, which its mechanism of action and treatment should be more investigated. mdma provides an immediate enjoyable feeling by stimulating the release of neurotransmitters, such as dopamine and serotonin in the brain. unfortunately, abnormal regulation of the brain neurotransmitters, as well as the increased oxidative stress causes damage to the brain neurons after the mdma exposure. only a few studies have been done regarding its treatment. thus, the treatment of mdma complications should be further explored mainly by targeting its mechanism of action in the neurotransmitter systems. hence, this study presents a short review regarding the recent findings on the role of neurotransmitters to cause mdma neurotoxicity. the results will be useful for future research in elucidating the potential treatment based on the targeted mechanisms to treat the neurotoxic effects of mdma.
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کلیدواژه
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Mdma ,Neurotransmitter ,Brain Injuries ,Memory ,Therapy
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آدرس
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University Of Sultan Zainal Abidin, Centre For Research In Addiction (Centrena), Faculty Of Medicine, Malaysia, University Of Sultan Zainal Abidin, Centre For Research In Addiction (Centrena), Faculty Of Medicine, Malaysia, University Of Sultan Zainal Abidin, Centre For Research In Addiction (Centrena), Faculty Of Medicine, Malaysia, University Of Sultan Zainal Abidin, Centre For Research In Addiction (Centrena), Faculty Of Medicine, Malaysia, University Of Sultan Zainal Abidin, Centre For Research In Addiction (Centrena), Faculty Of Medicine, Malaysia, University Of Sultan Zainal Abidin, Centre For Research In Addiction (Centrena), Faculty Of Islamic Contemporary Studies, Malaysia, University Of Sultan Zainal Abidin, Centre For Research In Addiction (Centrena), Research Institute For Islamic Products And Malay Civilization, Malaysia, University Of Sultan Zainal Abidin, Faculty Of Medicine, Faculty Of Islamic Contemporary Studies, Malaysia, University Of Sultan Zainal Abidin, City Campus, Faculty Of Medicine, Faculty Of Islamic Contemporary Studies, Malaysia, University Of Indonesia, Faculty Of Pharmacy, Indonesia, University Of Malaya, Faculty Of Medicine, Academic Unit Of Emergency Medicine, Malaysia
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Authors
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