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The Effects of 3,4-Methylenedioxy- Methamphetamine on Neurogenesis in the Hippocampus of Male Rats
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نویسنده
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Soleimani Asl Sara ,Ghasemi Moravej Fahimeh ,Kowsari Golshad ,Farhadi Mohammad Hassan ,Pourhaydar Bagher ,Ghasemi Hamidabadi Hatef ,Mehdizadeh Mehdi
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منبع
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Basic And Clinical Neuroscience - 2020 - دوره : 11 - شماره : 4 - صفحه:457 -464
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چکیده
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Introduction: the administration of 3,4-methylenedioxymethamphetamine (mdma) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. hence, this study evaluated the effects of mdma on neurogenesis in the hippocampus of male rats. methods: adult male wistar rats received intraperitoneal (ip) injections of mdma (10 mg/kg). we assessed nestin, sex-determining region y-box 2 (sox2), and neurod expressions according to the immunohistochemistry analyses. results: mdma reduced the expressions of nestin, sox2, and neurod compared with the control groups. the reduction in neurod expression was age-related. conclusion: mdma possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.
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کلیدواژه
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N-Methyl-3 ,4-Methylenedioxyamphetamine ,Hippocampus ,Nestin ,Sox2 Protein ,Neurod Protein
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آدرس
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Hamadan University Of Medical Sciences, Endometrium And Endometriosis Research Centre, Iran, Hamadan University Of Medical Sciences, Endometrium And Endometriosis Research Centre, Iran, Iran University Of Medical Sciences, School Of Advanced Technologies In Medicine, Iran, University Of Social Welfare And Rehabilitation Sciences, Subsance Abuse And Dependence Research Center, Iran, Urmia University Of Medical Sciences, Neurophysiology Research Center, School Of Medicine, Department Of Anatomy, Iran, Mazandaran University Of Medical Sciences, School Of Medicine, Department Of Anatomy And Cell Biology, Iran, Iran University Of Medical Sciences, Cellular And Molecular Research Center, School Of Medicine, Department Of Anatomy, Iran
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پست الکترونیکی
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maranaoo2004@yahoo.com
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Authors
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