Brain Connectivity Reflected in Electroencephalogram Coherence in Individuals With Autism: A Meta-Analysis

Introduction: many theories have been proposed about the etiology of autism. one is related to brain connectivity in patients with autism. several studies have reported brain connectivity changes in autism disease. this study was performed on electroencephalogram (eeg) studies that evaluated patients with autism, using functional brain connectivity, and compared them with typicallydeveloping individuals.methods: three scientific databases of sciencedirect, medline (pubmed), and biomed central were systematically searched through their online search engines. comprehensive metaanalysis software analyzed the obtained data.results: the systematic search led to 10 papers, in which eeg coherence was used to obtain the brain connectivity of people with autism. to determine the effect size, cohen rsquo;s d parameter was used. in the first metaanalysis, the study of the maximum effect size was considered, and all significant effect sizes were evaluated in the second metaanalysis. the effect size was assessed using a randomeffects model in both metaanalyses. the results of the first metaanalysis indicated that heterogeneity was not present among the studies (q=13.345, p>0.1). the evaluation of all effect sizes in the second metaanalysis showed a significant lack of homogeneity among the studies (q=56.984, p=0.0001).conclusion: on the whole, autism was found to be related to neural connectivity, and the present research showed the difference in the eeg coherence of people with autism and healthy people. these conclusions require further studies with more extensive data, considering different brain regions, and novel analysis techniques for assessing brain connectivity.