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The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain
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نویسنده
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Mehdizadeh Mehdi ,Katebi Majid ,Soleimani Mansoure ,Farahani Pad Mohammad Hassan ,Hoseini Tehrani S.Ali ,Joghataei Mohammad Taghi
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منبع
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basic and clinical neuroscience - 2010 - دوره : 1 - شماره : 3 - صفحه:17 -20
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چکیده
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Background & objective: even today there is no effective drug therapy to prevent neuronal loss after brain stroke. in the present study we studied the effect of mitochondrial katp channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. materials & methods: rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without k-atp channel regulators. results: neuronal ultrastructure significantly improved in k-atp channel opener (diazoxide) treated ischemia-reperfusion group compared with control group. conclusion: our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat.
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کلیدواژه
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Ischemia-Reperfusion ,Diazoxide ,Ultrastructural Changes
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آدرس
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iran university of medical sciences, School of Medicine, Department of Anatomy, ایران, hormozgan university of medical sciences, School of Medicine, Department of Anatomy, ایران, iran university of medical sciences, School of Medicine, Department of Anatomy, ایران, islamic azad university, School of Medicine, ایران, islamic azad university, School of Medicine, ایران, iran university of medical sciences, School of Medicine, Department of Anatomy, ایران
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پست الکترونیکی
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maranaoo2004@yahoo.com
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Authors
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