introducing genes with significant role in migraine: an interactomic approach

Introduction: migraine is a severe kind of headache with the chance hereditary of 50%. molecular studies can promote understanding of migraine pathophysiology. one of which is bioinformatics approach that could provide additional information related to the identified biomarkers. methods: in this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. through string database plug-in in cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. based on centrality and action types (expression, activation, and inhibition) genes were screened. results: numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. activation was dominate action relative to inhibition between the central genes. conclusion: the finding indicates that insulin is the most important gene relative to migraine. it seems regulation of metabolism play critical role in control of migraine.