Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neuron of the Ca1 Hippocampus in Rat Model of Alzheimer'S Disease

Introduction: donepezil (don), an acetylcholinesterase inhibitor (achei), is widely used in the treatment of alzheimer rsquo;s disease (ad). the current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in ca1 region of a rat model of ad.methods: in the current experimental study, adult male wistar rats were randomly divided into four groups: nucleus basalis magnocellularis (nbm) lesion (the lesions were induced by an electrical method of 0.5 m a, for 3 s in nbm) and three donepezil groups (lesions plus 5, 10, and 15 mg/kg donepezil intraperitoneal injection). neuronal spontaneous activity to injection of the donepezil and saline were recorded in ca1 region of hippocampal.results: the obtained results showed that intraperitoneal (ip) injection of donepezil (10 and 15 mg/kg) increased neuronal spontaneous activity in the rat model of ad.conclusion: the current study results suggested that acute ip injection of donepezil increased neuronal response in ca1 region of hippocampal in a rat model of ad.