The Effect of Systemic Amantadine Sulfate on Malondialdehyde and Total Thiol Levels in Rat Corneas

Purpose: to evaluate the malondialdehyde (mda) and total thiol (sulfhydryl,sh) levels in rat corneas after intraperitoneal injection of amantadine sulfate. methods: a total of 12 wistar albino rats were divided into two groups: control group (n = 6) and amantadine group (n = 6). balanced salt solution (1 ml,0.9% nacl,twice/day) was injected into rats in control group. amantadine sulfate (2 mg/1 ml,twice/day) was injected into rats in amantadine group. in each group,two rats were injected for 1 week,two received injections for 1 month,and two rats received injections for 3 months. the corneas were homogenized and mda and sh levels were measured spectroflourometrically. results: in control group,median mda and sh levels were 2.37 (range,0.92-3.60) and 25.35 (range,6.30-54.0) nmol/mg,respectively. in amantadine group,median mda and sh levels were 3.57 (range,1.25-5.92) and 32.65 (range,3.30-48.3) nmol/mg,respectively. the difference between this two groups regarding mda (p = 0.14) and sh (p = 1.0) levels was statistically insignificant. conclusion: systemically administered amantadine sulfate seems not to cause mda and sh imbalance in rat corneas.