Conjunctival Intraepithelial Neoplasia; Interferon Alpha‑2b; Ocular Surface Squamous Neoplasia; Ocular Surface Squamous Neoplasia

Purpose: to report the results of topical interferon alpha-2b (ifnα2b) for the treatment of ocular surface squamous neoplasia (ossn) with 360° limbal involvement. methods: in a prospective observational study,five patients with biopsy proven primary or recurrent ossn with 360° limbal involvement received topical ifnα2b (3 million iu/ml,4 times daily) and were followed from 8 to 12 months. outcome measures included resolution of the lesion,relief of symptoms,systemic and ocular side effects,and recurrence rate. results: five patients including 4 primary ossns and one recurrent ossn received topical interferon alpha-2b. the mean age was 60.2 (range: 52-73) years and mean follow up duration was 10.2 months. clinical resolution of the tumor occurred in all cases 2 months after initiation of treatment and no patient developed ocular or systemic complications. no recurrence of ossn developed during the follow up period. conclusion: topical recombinant ifnα2b appears to be an effective alternative treatment for ossn with 360° limbal involvement. this approach precludes the high risk of limbal stem cell deficiency which results from surgical excision or topical chemotherapeutic agents.