SUNY Eye Institute Proceedings: Delivery of Glutathione to the Lens Nucleus

Glutathione (gsh), an anionic tripeptide, is the principal antioxidant in the lens where it functions to maintain protein thiols in a reduced state. levels of gsh are high in both the epithelium and the outer cortex of the lens where the anti-oxidant is synthesized from the amino acids cysteine, glutamate and glycine by g-glutamylcysteinesynthetase and glutathione synthetase.