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Role of p58IPK in Endoplasmic Reticulum Stressassociated Apoptosis and Inflammation
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نویسنده
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Boriushkin Evgenii ,Wang Josh J. ,Zhang Sarah X.
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منبع
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journal of ophthalmic and vision research - 2014 - دوره : 9 - شماره : 1 - صفحه:134 -143
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چکیده
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The endoplasmic reticulum (er) is an essential site responsible for protein synthesis and maturation. newly synthesized polypeptide chains enter the er through a peptide translocon, and undergo maturation processes such as cleavage, glycosylation, disulfide bond formation, folding and assembly. perturbation of the protein maturation processes, caused by hypoxia, viral and bacterial infections, inhibition of protein glycosylation or disulfide bond formation, results in accumulation of unfolded and misfolded proteins in the lumen of the er. this condition is known as er stress. increased rate of protein synthesis and unbalanced protein folding capacity of the er can also lead to er stress.
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آدرس
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State University of New York, University at Buffalo, Ross Eye Institute, Department of Ophthalmology, USA. State University of New York, SUNY Eye Institute, USA, State University of New York, University at Buffalo, Ross Eye Institute, Department of Ophthalmology, USA. State University of New York, SUNY Eye Institute, USA, State University of New York, University at Buffalo, Ross Eye Institute, Department of Ophthalmology, Department of Biochemistry, USA. State University of New York, SUNY Eye Institute, USA
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Authors
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