Normobaric Oxygen Therapy for Scleral Ischemia or Melt

Purpose: to investigate the efficacy of normobaric oxygen (nbo) therapy for treatment of scleral ischemia or melt. methods: this prospective interventional case series includes 9 eyes of 8 patients with scleral ischemia or melt of diverse etiologies. following the failure of conventional medical and/or surgical therapy to improve ischemia or upon clinical deterioration, nbo was initiated. all patients received 100% nbo at flow rate of 10 liters/minute by face mask for 1 hour, twice daily until complete vascularization of ischemic areas. main outcome measures were improvement of scleral ischemia and healing of conjunctival epithelial defects. results: nbo therapy led to epithelialization and vascularization of the ischemic sclera in all eyes; the repair process began 3-4 days after nbo had been initiated and was completed in 18.1±4.7 (range, 10-25) days. all patients remained stable over a 9-month follow-up period. conclusion: nbo therapy seems effective for treatment of scleral ischemia or melt, and hence can be considered as a non-invasive alternative to surgical intervention in these conditions.