pharmacological treatment of presbyopia using pilocarpine 1.25% eye drops

Purpose:to assess the efficiency and safety of pilocarpine eye drop 1.25% analogue (ir- pilo) in comparison with its original brand-name drug (vuity).methods:in this non-randomized comparative study, 75 patients with presbyopia aged 40 to 60 years were enrolled. the right eyes of these patients received either ir-pilo (n = 45) or vuity (n = 30) and their contralateral eyes served as controls. refractive errors, distance best-corrected visual acuity (bcva), near vision, amplitude of accommodation, pupil size, and intraocular pressure (iop) were measured before and 1 to 2 hours after instillation of the eye drop.results:the mean refractive error was stable, except for a small myopic shift in the vuity group. there was no significant change in distance bcva. near vision improved significantly in both intervention groups (p < 0.001) with preference for ir-pilo (4 vs 2.3). furthermore, a higher amplitude of accommodation and pupil constriction occurred after instillation of both drops, with a higher effect associated with ir-pilo. however, iop did not change significantly post intervention.conclusion:ir-pilo and vuity eye drops had comparable results; both were effective and led to stable distance vision and improved near vision. both ophthalmic drugs were safe and none of them were associated with significant adverse effects.