Atypical Refractory Macular Edema: Are We Missing Something?

Purpose: to report a case of bilateral refractory macular edema in a diabetic macular edema in a diabetic with an underlying systemic illness. case report: a 65-year-old male presented with the symptom of blurred vision in both eyes for three months. he was a known diabetic patient and was also hypertensive for the last 10 years. the corrected distance visual acuity was 20/120 in the right eye and 20/80 in the left eye. fundus examination revealed multiple deep and superficial retinal hemorrhages, cystoid macular edema, and serous macular detachment in both eyes. with a diagnosis of diabetic macular edema in both eyes, the patient was treated with multiple intravitreal injections of anti-vascular endothelial growth factor and steroids. since he did not show a favorable response, the patient was further investigated and diagnosed with multiple myeloma. after undergoing treatment for the same, the patient was seen a year later and noted to have significant resolution of the macular edema and subretinal fluid in both eyes. conclusion: in patients who suffer with atypical macular edema that is resistant to conventional treatment, it is imperative to look for underlying systemic illnesses such as immunoproliferative disorders and hematologic malignancies.