Collagen Crosslinking for Keratoconus

In this issue of jovr, derakhshan and co- authors1 describe the results of crosslinking for patients with early keratoconus. collagen crosslinking is a recently described technique of corneal tissue strengthening using riboflavin as a photosensitizer and ultraviolet a (uva) radiation to promote the formation of intra- and interfibrillar covalent bonds by photosensitized oxidation.2 to date, it is the only published intervention that may retard the progression of keratoconus. collagen crosslinking has also been sequentially combined with other treatment modalities, namely intrastromal ring segments and photorefractive keratectomy, for treatment of keratoconus.3 other possible indications include keratectasia following laser in situ keratomileusis (lasik)4, infectious keratitis and bullous keratopathy5 .