comparison of retinal and choroidal involvement in sarcoidosis‑related chorioretinitis using fluorescein and indocyanine green angiography

Purpose: to compare the involvement of the retina with that of the choroid in ocular sarcoidosis (os) using dual fluorescein angiography (fa)/indocyanine green angiography (icga). methods: a retrospective study of 23 patients with the diagnosis of os was performed. angiographic signs were quantified following the established fa/icga scoring system for uveitis. results: the choroid was predominantly involved in 19 (82.6%) patients or 87% (40/46) of the eyes, and the retina in 2 (8.7%) patients or 13% (6/46) of the eyes. the mean angiographic score was 7.15 ± 4.5 for the retina (fa) compared to 14.02 ± 4.86 for the choroid (icga) (p < 0.0001). in 13% (3/23) of patients, fa did not show retinal inflammation, whereas icga was strongly positive, revealing occult choroidal lesions. conclusion: the choroid is preferentially involved in os, for which icga is the examination of choice. there is a risk of underestimating the global ocular involvement and of missing choroidal involvement if only fa is used. fa/icga scoring system allows for quantitative assessment of inflammation in the posterior uvea that occurs in os; therefore, the system can be useful to quantitatively monitor outcomes in clinical trials.