A Case of Wolfram Syndrome

Purpose: to report a case of wolfram syndrome characterized by early onset diabetesmellitus and progressive optic atrophy.case report: a 20-year-old male patient with diabetes mellitus type i presented withbest corrected visual acuity of 1/10 in both eyes with correction of -0.25+1.50@55 and-0.25+1.50@131 in his right and left eyes, respectively. bilateral optic atrophy wasevident on fundus examination. the patient also had diabetes insipidus, neurosensorydeafness, neurogenic bladder, polyuria and extra-residual voiding indicating atonyof the urinary tract, combined with delayed sexual maturity.conclusion: one should consider wolfram syndrome in patients with juvenile onsetdiabetes mellitus and hearing loss. ophthalmological examination may disclose opticatrophy; urologic examinations are vital in such patients.