Eyelid Carcinoma in Patients with Systemic Lymphoma

Purpose: to describe a series of patients with non-hodgkin’s lymphoma (nhl) andconcomitant eyelid carcinoma.methods: in this non-comparative interventional case series, we retrospectivelyreviewed the medical records of 5 patients with nhl who developed eyelid carcinoma.results: the patients included one female and four male subjects. systemic lymphomahad been diagnosed 1 to 72 months prior to development of the eyelid carcinoma.the lesions were basal cell carcinoma in three, and squamous cell carcinoma in twocases. the lymphoma was advanced (stage iii or iv) in all patients. four patientsunderwent surgical excision of the carcinoma and one patient was awaiting surgicaltreatment after completing systemic chemotherapy. three subjects had high-gradecarcinomas. two patients had perineural invasion; one received adjuvant radiotherapypostoperatively but the other did not due to receiving systemic chemotherapy forrecurrent nhl.conclusions: systemic lymphoma may be associated with aggressive eyelid carcinomas.perineural invasion is frequently encountered in this situation and should be treatedwith adjuvant radiation therapy to decrease the likelihood of local recurrence.