Long-term outcomes of amniotic membrane transplantation in contact lens-induced pseudomonas keratitis with impending corneal perforation

Purpose: to report the anatomical and visual outcomes of double layered amniotic membrane transplantation (amt) in eyes with advanced pseudomonas keratitis leading to descemetocele formation. methods: this prospective interventional case series included 6 eyes of 6 female patients with pseudomonas keratitis caused by contact lens-induced infection who underwent double layered amt. surgery was performed after the ulcers were found to be poorly responsive to antibiotics,and severe thinning or descemetocele had developed. all patients underwent a complete examination pre- and postoperatively,as well as anterior segment optical coherence tomography (oct) and pachymetry or orbscan after the procedure. results: mean follow-up period was 24 months. there was neither frank corneal perforation nor a need for emergent corneal transplantation in any of the eyes. all patients had visual acuity of hand motions before the procedure which improved to 20/50 to 20/30 three months after surgery. no surgical or postoperative complication occurred in this series. conclusion: double layered amt may result in acceptable anatomical outcomes in patients with advanced pseudomonas keratitis with descemetocele formation and can eliminate the need for emergent corneal transplantation. © 2016 journal of ophthalmic and vision research.