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The role of mitochondria in AMD: Current knowledge and future applications
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نویسنده
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riazi-esfahani m. ,kuppermann b.d. ,kenney m.c.
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منبع
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journal of ophthalmic and vision research - 2017 - دوره : 12 - شماره : 4 - صفحه:424 -428
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چکیده
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Mitochondria are organelles which comprise the main respiratory machinery in the eukaryotic cells. in addition to their crucial role in energy production,they have profound effects on apoptosis and retrograde signaling to nucleus. mitochondria have their own dna,which codes for different proteins mostly involved in oxidative phosphorylation. significant changes in the mitochondria of retinal pigment epithelium have been reported in age-related macular degeneration (amd),which is correlated with the severity of the disease. cybrid cell lines that have identical nuclei but mitochondria from different individuals can provide a unique means for studying the relationship between mitochondria and amd. different approaches for protection of mitochondria have been introduced which can be considered as potential future treatments for amd and other age- related disorders. © 2017 journal of ophthalmic and vision research | published by wolters kluwer - medknow.
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کلیدواژه
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Age-related Macular Degeneration; DNA; Mitochondria; Mitochondrial
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آدرس
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department of ophthalmology,university of california irvine,gavin herbert eye institute,ophthalmology research laboratory,irvine,ca,united states,eye research center,farabi eye hospital,tehran university of medical sciences,tehran, ایران, department of ophthalmology,university of california irvine,gavin herbert eye institute,ophthalmology research laboratory,irvine,ca,united states,department of biomedical engineering,university of california irvine,irvine,ca, United States, department of ophthalmology,university of california irvine,gavin herbert eye institute,ophthalmology research laboratory,irvine,ca,united states,department of pathology and laboratory medicine,university of california irvine,irvine,ca, United States
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Authors
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