Outcomes of Photorefractive Keratectomy with Intraoperative Mitomycin-C

Purpose: to report the efficacy, safety, predictability and complications of photorefractivekeratectomy (prk) with intraoperative application of mitomycin-c (mmc).methods: this historical cohort study was performed on 1,250 eyes of 625 patients whounderwent prk using the technolas 217 excimer laser machine by a single surgeon withintraoperative use of mmc 0.02% up to 2 minutes, depending on depth of ablation. acomplete ophthalmologic examination was performed which included refraction,uncorrected visual acuity (ucva), best-corrected visual acuity (bcva) and slitlampbiomicroscopy. outcomes were analyzed after one year of follow-up.results: the mean preoperative spherical equivalent refractive error was -4.85±2.27(range, -2.50 to -13.5) diopters (d). mean depth of ablation was 89±22 microns and meantime to reepithelialization was 4.5±1.7 days. at final follow-up, ucva of 20/20 and20/40 or more was achieved in 92.1% and 99.2% of eyes, respectively. one year postoperatively,69.4% and 91% of eyes were within ±0.50 d and ±1.00 d of emmetropia.overall, 62 eyes (4.9%) developed one or two lines of decrease in bcva, and 50 eyes(4%) developed corneal haze which was grade 1 or 2 in most cases; grade 3 and 4corneal haze was found in 4 and 2 eyes, respectively. no other adverse event was notedduring the study period.conclusion: prk with intraoperative application of mmc provides excellent visualoutcomes with acceptable safety and predictability, and entails minimal side effects.