شاخصهای چاقی موشهای صحرایی تغذیه شده با رژیم غذایی C اثر ویتامین پرچرب

Background and objective: vitamin c is abundant and easily eaten. according to some reports, its level is lower in obese individuals. thus in order to investigate the effect of different levels of vitamin c on food and energy intake and anthropometric indices, obese rats on high-fat diets, were treated by ascending amounts of vitamin c in drinking water.subjects and methods: forty male sprague dawley rats (160 ± 10 g) were used. animals were divided into five groups; control, high fat (hf), high fat+250mg/l vitamin c (hf250), high fat+500mg/l vitamin c (hf500) and high fat+1000 mg/l vitamin c (hf1000). control group was fed by the standard pellets and high-fat groups were fed by diets containing 31% fat. vitamin c was added to the drinking water of treated groups and the amount of water and food consumption, weight gain and obesity-related indices were compared during the 8-week between the studying groups. results: a high-fat fed diet increased energy intake, weight gain, fat storage (p < 0.05), plasma total cholesterol and ldl-c (p < 0.01). although high level of vitamin c increased food and energy intake (p < 0.01), medium and high doses caused partial control of weight gain and fat storage. conclusions: addition of 500 and 1000 mg/dl vitamin c in drinking water decreased weight gain and fat storage in the high-fat fed animal, which may suggest its usefulness for inhibition of obesity related disorders.