bicytopenia secondary to autoimmune myelofibrosis as the first presentation of an undiagnosed systemic lupus erythematosus: a rare case report

Autoimmune myelofibrosis (aimf) is considered as an infrequent cause of bone marrow fibrosis (bmf) and a rare complication of systemic lupus erythematosus (sle). due to its rarity, it is mistakenly diagnosed as primary myelofibrosis (mf).we describe the clinicopathologic features of a secondary form of aimf in a 33- year- old female patient with an undiagnosed sle which presented with acute bicytopenia. absence of splenomegaly, leukopenia, anemia, bmf (grade mf-1), and presence of autoantibodies were some of noticeable features. treatment with corticosteroid led to complete regeneration of the bone marrow and subsequently to an improved hematological status. six- month follow-up showed that the patient was in good clinical condition.identification of aimf is a diagnostic challenge and pitfall and it is actually a diagnosis of exclusion. it could be the first and only presenting feature of sle and results in hematologic disturbances. so, we should consider sle-associated aimf in the differential diagnosis of pancytopenia.