investigating the therapeutic effect of β-interferon and methylprednisolone on covid- 19 patients’consequence: a non- randomized, double-blinded, controlled study

Background & objective: due to the severe inflammatory conditions and cytokine storm in covid-19 disease, corticosteroids are used worldwide as adjunctive therapy for these patients due to their anti-inflammatory effects. however, due to limited and inconsistent information about the effectiveness of this drug, this study aimed to investigate the benefit of combined use of β-interferon and methylprednisolone in patients with covid-19.materials & methods: 57 patients infected with sars coronavirus 2 underwent treatment. laboratory parameters, hospitalization duration, and clinical outcomes in these patients were studied.results: statistical analysis showed no correlation between combination therapy with the hospitalization duration (p=0.22) and mortality (p=0.48). also, the findings of this study showed that the esr level in patients receiving combination therapy with methylprednisolone and interferon beta decreased significantly at the end of the intervention (p=0.0001). at the end of the study, the levels of neutrophils (p=0.001) and lymphocytes (p- value=0.0001) in the blood in the interferon group showed a significant change.conclusion: this study showed no effect of adding methylprednisolone and interferon beta to the treatment protocol on mortality in the patients.