probiotic enterococcus durans interference with oral candida albicans adhesion: an in vitro study

Background & objective: candida species, and most frequently isolated candida albicans, are normal microorganisms of oral cavities; however, c. albicans is responsible for oral cavities in children with dental caries. as a new biologic technique, using probiotics has gained popularity in preventing and controlling diseases at present. enterococcus durans has exhibited useful antioxidative properties and antibacterial and probiotic characteristics. this study aims to evaluate the effects of probiotic enterococcus durans on the in vitro adhesion of candida albicans. materials & methods: reference bacteria strain of probiotic e. durans (atcc 6056), c. albicans reference strain (ptcc-5027), and 10 clinical samples of c. albicans were provided. adherence inhibition of candida albicans was measured using microtiter plates applying two methods (addition of a mixed suspension of c. albicans and e. durans simultaneously and addition of e. durans 30 minutes before c. albicans). data were analyzed with a repeated measure model. statistical significance was set at p-value<0.01. results: adhesions of c. albicans biofilms decreased in the presence of the probiotic strain e. durans. mean od620 nm was within the range of 0.45 to 0.49, and 0.33 for od490 nm . conclusion: using e. durans as a probiotic could reduce candida albicans adhesion and, therefore, can be considered as an effective way to decrease its pathogenicity.