a narrative review on evaluation of hypercoagulability state in severe covid-19 patients with background risk factors

Coronavirus disease (covid-19) can induce coagulopathy at the base of sepsisinduced coagulopathy (sic), which is an important cause of death in these patients. cytokine storm causes imbalance in coagulation and fibrinolytic system. a combination of hypercoagulability state, decrease or inhibition of fibrinolysis and endotheliopathy causes thromboembolic events. underlying diseases such as diabetes and hypertension with a high rate of mortality in covid-19 and some conditions like aging and obesity are the main disorders with hemostatic disturbance and increase of coagulopathy. therefore, it seems that the combination of covid-19 infection and these risk factors increase the risk of thromboembolic complications all together.