comparison of the blink reflex and r2 recovery cycle parameters between blepharospasm and healthy subjects

Background objective: the blink reflex recovery cycle indicates the excitability of interneurons in the brainstem. in this study, we aimed to investigate the blink reflex and r2 recovery cycle in patients with benign essential blepharospasm (beb). materials methods: this prospective casecontrol study compared the blink reflex and r2 recovery in 18 beb patients with 18 age and gendermatched healthy individuals. the blink reflex was measured in a stimulation duration of 0.2 ms, and r1, r2, and r2 rsquo; were recorded for all subjects. the r2 recovery cycle was measured by stimulation of the supraorbital nerve at four interstimulus intervals (isi) of 200, 300, 500, and 1000 ms, with the same intensity as the previous test. the r2 recovery index was calculated and compared with the control group via independent sample ttest. twotailed pvalue less than 0.05 was considered statistically significant. results: the blink reflex (r1, r2, and r2 rsquo; responses) distal latencies and amplitudes in the beb group were not significantly different from the control group (p>0.05). the r2 recovery index in all intervals was significantly higher in the beb group than the control group (p=0.00). the most significant difference between the beb and control groups regarding the r2 recovery indices was observed at isis of 300 and 200 ms (80.36 vs. 16.99 and 75.70 vs. 12.57, respectively). there was a negative correlation between the patient rsquo;s age at the onset of disease and the r2 recovery index; however, it was not statistically significant (p>0.05). conclusion: our findings showed that the r2 recovery reflex was higher in beb patients than the normal population. therefore, it can be a helpful index for differentiating beb cases from psychogenic or malingering ones.