effect of 8 weeks aerobic training and nigella supplement on insulin resistance, lipid profile and plasma level of hba1c in type 2 diabetic rats

Background & objective: metabolic syndrome is defined as a cluster of metabolic disorders, which may lead to type ii diabetes and cardiovascular diseases. the aim of this study was to investigate the effect of 8 weeks of aerobic training and nigella sativa supplements on insulin resistance, lipid profiles, and plasma levels of hba1c in type 2 diabetic rats. materials & methods: 35 male wistar rats were divided into five groups. diabetes was induced by intraperitoneal injection of streptozotocin. the training program included 8 weeks of aerobic training on a treadmill. the supplement group consumed n. sativa supplement at the end of each training session at the dose of 400mg/kg/day. after 8 weeks of aerobic training and n.sativa consumption, the plasma levels of hba1c, insulin resistance and lipid profiles were measured. results: the results showed that blood glucose level in all three groups was significantly lower than the baseline (p=0.0001). cholesterol, triglyceride and ldl showed the most significant decrease in aerobic and combination training groups (p=0.0001). in hdl index, aerobic and combined exercise groups showed a significant increase (p=0.0001). hemoglobin a1c index and insulin resistance in the combination group showed a significant decrease compared to the other groups (p=0.0001). conclusion: the results shows that exercise along with n. sativa supplement is more effective than n. sativa supplement or exercise alone in the status of rats with type 2 diabetes. this kind of combination therapy may also be applicable to diabetic patients.