the effect of bone marrow derived mesenchymal stem cells on the survival of random skin flap on sterptozotocin-induced diabetic rats

Background & objective: wound dressing and healing in diabetic patients is encountered with many problems. this study aimed to investigate the effect of bone marrow derived mesenchymal stem cells (bm-mscs) on the survival of random skin flap (rsf) on streptozotocin-induced diabetic rats (stz) using an optical microscope. materials & methods: in this study, 60 male albino wistar rats were used (average weight 250-300 gr). the rats were divided into six groups: 1) health-non (hn), 2) health-cells (hc), 3) health-sham (hs), 4) diabetic-non (dn) that were became diabetic by injecting stz 70 mg/kg intraperitoneally), 5) diabetic-sham (ds), and 6) diabetic-cell (dc). in all groups, the day of surgery was considered as the zero day, on the back area of animal, the flap was created with a size of 8 × 3 cm and the bm-mscs were performed. the sampling was performed on day 7 after surgery from the region where transitional zone (tz) necrosis was initiated. results: bm-mscs increased the number of blood vessels (p=0.009) and the histology parameters (wound demarcation p=0.0001, granulation tissue p=0.0001) significantly compared to the control group. but this increase was not significant in the area of the survival region. conclusion: it was concluded that after treatment with bm-mscs, the wound healing process in both non-diabetic and diabetic groups was increased in accordance with histological characteristics.