evaluation of the relationship between serum acth and uric acid levels and insulin resistance in patients with type 2 diabetes

Background: research indicates that high levels of uric acid (ua) are linked to insulin resistance (ir), which may elevate the risk of diabetes development. adrenocorticotropic hormone (acth) regulates cortisol, a hormone essential for glucose metabolism. this study examined the relationship between acth, uric acid (ua) levels, and ir in diabetic patients.methods: this case-control study involved thirty individuals with type 2 diabetes (t2d) and 30 healthy controls (45% male and 55% female) in iran. demographic data were collected, and serum levels of acth and insulin were assessed using elisa; serum ua levels were measured through spectrophotometry. the data were analyzed using spss version 24.results: significant differences were observed in body mass index (bmi), fasting blood sugar (fbs), hba1c, and ir, with higher mean values in the t2d group compared to the control group (p<0.05). ua levels were significantly elevated in all patients (p=0.004), particularly males (p=0.009), compared to controls. moreover, increased ua levels were linked to greater disease risk (p=0.007). acth levels were also significantly higher in t2d individuals than in healthy individuals (p<0.001), and elevated acth levels correlated with an increased disease risk (p=0.002). additionally, the relationship between acth and ua levels and ir in the t2d group was significant compared to the control group.conclusion: the findings indicate a relationship between acth, ua, ir, and t2d, suggesting that these factors may serve as important indicators for diagnosing the progression of the disease.